However, again, it’s worth noting that it was a retrospective study based on a patient’s medical history. In the 2020 study mentioned above, artisanal CBD was associated with a 70 percent increase in seizures, which may have been due to THC content. Can cannabis or CBD make seizures worse or more frequent? In some studies, a few subjects actually experienced an increase in seizures after using CBD. There is a chance that CBD can cause side effects. Is CBD oil safe for epilepsy? Are there risks of taking CBD for epilepsy? Because of the risks associated with THC, it’s important to discuss any treatments you take with a doctor who understands your medical history. However, as the authors pointed out, this will have to be explored by more study before any conclusions can be drawn.Īnecdotally, people have used CBD-rich cannabis for epilepsy. The meta-analysis concluded that CBD-rich cannabis extracts were actually more effective at reducing seizures than pure CBD. However, one 2018 meta-analysis compared the effects of pure CBD with CBD-rich cannabis extracts on treatment-resistant epilepsy. THC may also be addictive and cause bad reactions for some people, especially if used in large quantities. ![]() In larger doses, THC may even have proconvulsant properties. More research needs to be done specifically on THC, the other major cannabinoid found in cannabis, as an anticonvulsant. It’s not clear whether cannabis is better at reducing seizures than CBD alone. Medical cannabis may be effective in the treatment of epilepsy because it contains CBD. It was also a small study, with 31 subjects and only 9 taking artisanal CBD. It was a retrospective study - meaning it involved looking back at a patient’s history instead of following it over time. It’s important to note that artisanal CBD can have varying levels of THC and may not undergo testing, which may have contributed to the increase in seizure activity. Those who took artisanal CBD had a 70 percent increase in seizures during the study period, while those taking prescription CBD had a 39 percent reduction in seizures. One recent study compared the effects of artisanal, or store-bought, CBD with that of pharmaceutical-grade CBD on people with epilepsy, and it highlighted the potential risks with opting for store-bought CBD over Epidiolex. Commercial CBD isn’t regulated by the FDA. Because Epidiolex is a pharmaceutical product, it’s held to higher manufacturing standards than commercial CBD. However, they also noted there are potential side effects of Epidiolex.Īlthough CBD is the basis of Epidiolex, using store-bought CBD is not exactly the same as using Epidiolex. The studies suggested that Epidiolex reduces the frequency of seizures. Both of these studies were conducted on the effects of Epidiolex on Dravet syndrome and Lennox-Gastaut syndrome. Randomized, double-blind, placebo-controlled studies are considered the “gold standard” of clinical trials because they reduce the chance of bias and include a control. According to the FDA website, they grant an approval if they conclude that “the benefits of the product outweigh the known risks for the intended use.” Instead, the product’s manufacturer conducts laboratory, animal, and human clinical testing. Since these seizure conditions typically affect children and teenagers, Epidiolex is usually prescribed for children with epilepsy.īut what exactly does it mean to have FDA approval? The FDA itself doesn’t test products. It also approved of the use of Epidiolex to treat tuberous sclerosis complex, another rare seizure condition. In 2020, the FDA approved Epidiolex for people 1 and older. ![]() The FDA initially approved the use of Epidiolex to treat two rare forms of epilepsy, Lennox-Gastaut syndrome and Dravet syndrome, in people 2 and older. There is only one CBD-based epilepsy medication approved by the Food and Drug Administration (FDA): Epidiolex.
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